Gemcitabine is among the most efficacious and widely used antimetabolite agents.Its molecular targets are ribonucleotide reductase M1 (RRM1) and elongating DNA.Acquired and de novo resistance as a result of RRM1 overexpression are major obstacles to therapeutic efficacy.We deployed a synthetic lethality screen to investigate Mushroom Gummies if kno
Heterozygous loss-of-function mutation of the calcium sensing-receptor (CaSR), causes familial hypocalciuric hypercalcemia type 1 (FHH1), a typically benign condition characterized by mild hypercalcemia.In contrast, homozygous mutation of this dimer-forming G-protein coupled receptor manifests as the lethal neonatal severe hyperparathyroidism (NSHP
Heritage is increasingly present in educational discourses, yet research on heritage Supplies education still lacks literature overviews that identify trends in its scientific production worldwide in order to get to know the discipline’s advances, evolution, and impact.This article collected a bibliographic review of n = 223 documents indexed in
Wooden Dollhouse Accessories Abstract This paper measures the effect of a long-term career interruption on wages after re-employment.Using data from the Swiss Household Panel (SHP) and a fixed effects estimation method allows us to account for time-constant unobserved heterogeneity.We find a significant wage penalty of about 7% in the first year af